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KMID : 0358419960390040647
Korean Journal of Obstetrics and Gynecology
1996 Volume.39 No. 4 p.647 ~ p.652
A Comparison of Two Protocols in Oxytocin Induction of Labor, Gradual and Double Increment in Oxytocin Dose
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Abstract
Objective:
@EN To compare the efficacy and safety of two oxytocin induction protocols that differ in oxytocin dose increment.
@ES Study design:
@EN Two hundred and three women admitted for induction of labor were prospectively randomized into one of two oxytocin induction protocols. Starting at 2mU/min, the amount of oxytocin infused was gradually increased in 102 women(protocol A) and
increased by doubling the previous dose in 101 women(protocol B). The efficacy and safetyof the two protocols were analyzed with student t test, x*, and Fisher's exact test.
@ES Results:
@EN No differences were observed in confounding clinical and demographic factors between the two groups. There were no statistically significant differences in the maximum and adequate infusion rate of oxytocin, duration of labor, and neonatal
outcome.
Howere, the incidence of uterine hyperstimulation and adnormal fetal heart rate patterns was significantly different between two groups(2%, 16.7% in protocol A versus 15.8%, 32.5% in protocol B, respectively, p<0.05).
@ES Conclusion: For the oxytocin induction of labor at term, gradual increment method was superior to that by double dose increment in reducing the incidence of uterine hyper-stimulation and abnormal fetal heart rate, while showing same efficacy.
KEYWORD
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